Archive for November 9th, 2008

American Journal of Critical Care - An initially unsuspected case of baclofen overdose

Sunday, November 9th, 2008

Baclofen, a derivative of [gamma]-aminobutyric acid, is used for symptomatic relief of skeletal muscle spasm and spasticity, particularly in patients with multiple sclerosis. (1) Although its exact mechanism is not fully understood, its main effects at the spinal end of upper motor neurons are thought to cause muscle relaxation. Adverse effects of baclofen a…